'PIVKA-II AND HEPATIC PATHOLOGIES. HOW CAN A RELATION BE DEFINED

Abstract

Objective:  To  observe  the  levels of PIVKA-II and its correlation with various hepatic pathologies and defining relation between them.

Study Design:  A  Cross  sectional  observational  study

Study Duration:  06  months 

Study Place:  Tertiary  Care  Hospital,  Lahore

Methods:  A  cross-sectional  observational  study  was  conducted  over  six  months  in  the  Gastroenterology  Department  of  a  tertiary  care  hospital  in  Lahore.  Using WHO Sample Size Calculator, a sample size of 312 patients was calculated. Data  were  analyzed  using  SPSS  25,  with  significance  set  at  p<0.05.  Ethical approval  was  obtained  beforehand.

Results:  312 patients were included in our study, among them 112 were males and 100 were females. Patients were divided into the 03 groups i.e. hepatocellular carcinoma, cirrhosis and chronic hepatitis. PIVKA-II levels were measured in all the groups. Patients with hepatocellular carcinoma showed a significant increase in levels of PIVKA-II as compared to other groups. PIVKA-II levels were ranging in 690±5 in hepatocellular group.

Conclusion:  PIVKA-II serves as a significant important marker in assessing diseases of liver esp liver carcinoma, cirrhosis and chronic hepatitis. Its elevation helps guide treatment protocols and further management.